Evaluación de la efectividad del tratamiento con alteplasa en pacientes con infarto agudo de miocardio en el Hospital Teodoro Maldonado Carbo 2022-2023.

Abstract

Introduction: Acute myocardial infarction (AMI) is one of the leading causes of morbidity and mortality worldwide. Thrombolytic treatment with alteplase has proven effective in restoring coronary blood flow, improving patient outcomes when administered in a timely manner. Objective: To evaluate the effectiveness of alteplase treatment in AMI patients treated at the Teodoro Maldonado Carbo Hospital in Guayaquil during the period from 2022 to 2023. Design and Methodology: A retrospective, observational, and analytical study was conducted, including 176 patients diagnosed with AMI, 47 of whom were treated with alteplase. Variables such as ejection fraction and infarct size before and after alteplase administration, as well as mortality, were analyzed. Results: A total of 47 patients treated with alteplase achieved successful reperfusion without fatal complications in 87.2% and 12.8%, respectively. It also contributed to the reduction of infarct size and improved ventricular function, with descriptive data supporting that alteplase improves myocardial flow. Alteplase therapy in patients who suffered acute myocardial infarction at the Teodoro Maldonado Carbo Hospital during the analyzed period demonstrated high clinical effectiveness. K