Estimación del filtrado glomerular mediante ecuaciones específicas para cirróticos hospitalizados en el Hospital General del Norte de Guayaquil Los Ceibos 2018-2023.

Abstract

Introduction: Hepatic cirrhosis represents a significant challenge in terms of public health due to the scarcity of organs for liver transplants, which is the only effective solution. Accurate assessment of renal function is essential to expand the candidate list and improve postoperative outcomes. Objectives: In this study, we aimed to compare glomerular filtration rate estimations obtained using the standard equation (CKD-EPI) with two other equations (RFH-GFR and GRAIL) in cirrhotic patients, and analyze associated discrepancies and findings. Materials and Methods: The study adopted a cross-sectional, observational, retrospective, and analytical approach, using the SPSS program for statistical analysis. Results: The distributions of CKDEPI, RFH-GFR, and GRAIL equations did not follow a normal distribution. Statistically significant differences were found between RFH-GFR and CKDEPI equations, and between GRAIL and RFH-GFR, while no significant differences were observed between GRAIL and CKD-EPI. Additionally, a positive correlation was identified among the different equations, with the strongest correlation between CKD-EPI and RFH-GFR. Discussion: It is highlighted that the RFH-GFR equation tended to produce lower glomerular filtration rate values compared to CKD-EPI and GRAIL, while GRAIL showed results similar to CKD-EPI. Conclusion: Glomerular filtration rate rates estimated by the three equations differed significantly from each other, underscoring the importance of carefully considering the choice of equation in the evaluation of cirrhotic patients for liver transplantation.