Utilidad del índice aspartato amino transferasa/plaquetas como predictor de mortalidad en cirrosis hepática durante el período 2019- 2020 en el Hospital Teodoro Maldonado Carbo.

Abstract

Introduction: Liver cirrhosis is a clinical pathology characterized by replacement of normal nodular hepatic tissue by regeneration nodules, which will alter their architecture as they are eminently fibrotic tissue. Currently we have available specific serological markers such as the aspartate amino transferase/platelet index (APRI), which is a non-invasive method that helps us to detect hepatic fibrosis in chronic liver disease carriers. The present study seeks to establish the usefulness between the APRI index and mortality in cirrhotic patients. Methodology: A historical, quantitative, observational, retrospective and cross-sectional cohort study was conducted, where the sample included 286 patients with a diagnosis of liver cirrhosis, data collection was performed from the review of medical records of the institution's system AS400, Hospital Teodoro Maldonado Carbo in the period between 2019 and 2020 tabulated in a Microsoft Excel spreadsheet and processed and statistically analyzed in the SPSS program. Results: A sample of 286 cirrhotic patients was obtained, of which 56% were male and 44% female; a total of 125 men and 90 women died; for the different variables correlated with mortality in patients with liver cirrhosis, the following was obtained: Duration of the disease in years OR: 0. 83 (CI - 95%: 0.73 - 0.94, p=0.005), sex OR: 0.55 (CI - 95%: 0.27 - 1.09, p=0.09), APRI index OR: 1.22 (CI - 95%: 1.03 - 1.46, p=0. 02), age in years OR: 1.05 (CI - 95%: 1.02 - 1.09, p=0.001) and survival rate by Child Pugh scale at two years OR: 0.00 (CI - 95%: 0.00 - 0.00, p=0.00). Conclusions: The presence of severe fibrosis according to the APRI index in cirrhotic patients was associated with higher mortality. Which can be established as a good predictor of mortality. The greatest age range was those older than 65 years; the etiology was mostly non-alcoholic and mortality in our study was 75.17%.