Incidencia neuroinfecciones en pacientes con VIH/SIDA que desarrollan síndrome inflamatorio de reconstitución inmunológica (SIRI) en el hospital Teodoro Maldonado Carbo desde enero del 2017 hasta diciembre de 2018.

Abstract

Introduction: SIRI (Inflammatory Immunological Reconstitution Syndrome) is described as a worsening of the clinical status of patients with HIV / AIDS, after the start of high antiretroviral treatment (HAART) caused by an improvement in the immunological status and therefore its capacity of acting against infectious agents. SIRI can be triggered by a series of pathogens, including neuroinfection precursors. Objective: To estimate the prevalence of neuroinfections in patients who have developed SIRI with a diagnosis of HIV / AIDS at Teodoro Maldonado Carbo Hospital during January 2017 to December 2018. Methodology: A non-experimental, observational, retrospective and descriptive study was carried out. The information was obtained from the clinical records of the AS400 system of patients who met the inclusion and exclusion criteria. A database was developed in the Microsoft Office Excel 2013 program. The respective analysis was performed and the results obtained were generated tables and graphs. Results: Of 5321 patients diagnosed with HIV with HAART treatment, they obtained a random sample of 350 patients with a 95% confidence interval, where they obtained 8 patients (2%) who developed neuroinfections related to the appearance of SIRI in patients with HIV diagnosis with TARGA treatment, at the Teodoro Maldonado Carbo Hospital. In addition, it was possible to determine the neurological pathologies related to Toxoplasmosis (37.5%), Histoplasmosis and Cryptococcosis (25%) and LMP (12%), developed more frequently in males (88%) than in females (12%).