Plasma rico en fibrina como estrategia biológica en exodoncias. UCSG A-2025. Estudio clínico.

Abstract

Introduction: The use of advanced platelet-rich fibrin (A-PRF) is a potential strategy to accelerate soft-tissue healing, control inflammation, and reduce complications after third-molar extraction. Objective: To evaluate the effect of A-PRF on postoperative healing following mandibular third-molar extractions. Methods: Split-mouth, intra-individual quasi-experimental design in 21 patients undergoing extraction of mandibular third molars; A-PRF was applied to one socket and not to the contralateral socket. Results: Using the Landry wound healing index, at day 7 the A-PRF side showed mostly adequate healing (57.1%), followed by fair (38.1%). In the control side, most cases were very poor (52.4%), followed by fair (42.9%), with significant differences between sides (p < 0.05). At day 14, the A-PRF side showed a significant majority with excellent healing (71.4%), whereas the control side was mostly good (71.4%) with some fair cases remaining; differences were significant (p < 0.05). Across all outcomes assessed—pain, degree of inflammation, and trismus—the A-PRF side outperformed the control. No patient developed alveolar osteitis. By day 14, most clinical signs had resolved, achieving satisfactory healing in 100% of patients. Conclusions: A-PRF demonstrated superior postoperative healing after mandibular third-molar extraction in this cohort.