Caracterización clínica de trombofilias en pacientes pediátricos atendidos en el Hospital “Dr. Roberto Gilbert Elizalde” de enero 2018 a diciembre 2022.

Abstract

Thrombophilia is the term used to describe the tendency to develop thrombosis or its recurrence, its prevalence is highly variable depending on the population studied. Thromboembolic events are rare conditions in pediatric patients and are associated with congenital or acquired factors. Common inherited thrombophilias include protein C and S deficiencies, factor V Leiden mutation, prothrombin G20210A mutation and antithrombin III deficiency, while acquired thrombophilias often involve antiphospholipid antibodies and the use of central venous catheters. Currently, the prevalence of thrombotic events associated with primary or secondary thrombophilias in the local population has not been defined, so this paper attempts to describe the clinical characteristics of pediatric patients diagnosed with primary or secondary thrombophilias at the "Dr. Roberto Gilberto Elizalde" Children's Hospital. 159 patients were found eligible for analysis, with a marked male predominance, mean age of 5 years, the most frequent cause of secondary thrombosis was the presence of a catheter and in the case of primary thrombophilia the most frequent cause was protein deficiency. C. Most patients were treated with low molecular weight heparin.