Eficacia del score SOFA al día de ingreso vs biomarcadores endoteliales a las 24 horas para evaluar pronostico en la mortalidad de pacientes con Shock séptico en la unidad de cuidados intensivos en el Hospital Abel Gilbert Pontón desde el año 2022 al 2023.

Abstract

Introduction: Septic shock is a type of distributive shock, which results from a progression of sepsis that is a deregulated response of the host towards an infection causing organ dysfunction. Therefore, septic shock is clinically defined as a patient who meets sepsis criteria and despite adequate fluid resuscitation, requires vasopressors to maintain a mean arterial pressure (MAP) ≥65 mmHg and who maintain blood lactate levels. >2 mmol/L (>18 mg/dL). Objective: Assess the effectiveness of the SOFA Score on the day of admission with endothelial biomarkers 24 hours after admission to determine the prognostic value in patients with septic shock in the intensive care unit at the Abel Gilbert Pontón hospital from 2022 to 2023. Method: The study is observational, retrospective and analytical, consisting of a universe of 181 patients, of which 96 patients met the inclusion criteria. Results: The female sex has a higher risk of developing sepsis with 50.5%, the age group represent between 61 and 70 years. The days spent in the intensive care unit average 6 days. Regarding SOFA Score vs Biomarkers, the SOFA Score has the largest area under the curve (AUC) of 0.931, with 95% confidence interval between 0.872 and 0.991, indicating an excellent ability to differentiate between positive and negative groups, proving to be better than biomarkers that have a lower AUC. PCR (0.668), PCT (0.774), LDH (0.686). Conclusions: The SOFA score is the most effective tool to predict mortality in patients with septic shock.