Determinación de hiperprolactinemia en pacientes con síndrome de ovario poliquístico en mujeres de 18 – 25 años de edad en el Hospital General del Norte de Guayaquil IESS Los Ceibos periodo enero 2017 – octubre 2019.

Abstract

Introduction: Polycystic ovary syndrome (PCOS) is a pathology characterized by hyperandrogenism, ovulatory dysfunction and ovarian polycystosis. Insulin resistance in patients with polycystic ovary syndrome has been shown to have a genetic association, and there are patients with this clinical entity who do not appear to have insulin resistance. Insulin resistance is increased in obese populations, and weight loss has been shown to improve this endocrine profile and increase the likelihood of menstruation with ovulation. Among the various associations that PCOS presents, there are data that allow us to find an association between hyperprolactinemia and PCOS. Despite the existence of this relationship, the results are mixed, with various studies finding that this association does not exist. Methods: Retrospective, observational and analytical study. The data was extracted from patients admitted to the IESS Ceibos Hospital during the last 3 years (january 2017 – octuber 2019) with a diagnosis of polycystic ovary syndrome. The population was obtained by a non-randomized samplin. Results: T3 levels greater than 3 ng / dl seem to be a risk factor for the development of hyperprolactinemia (OR 1,377, 95% CI, 1.09 - 2,044), as well as the absence of hyperprolactinemia proves to be a protective factor for the development of thyroid abnormalities with an OR of .783 (95% CI, .616-. 994). In PCOS patients with hyperprolactinemia, there is a 1.7 times greater risk of developing primary thyroid disorders than the PCOS population without hyperprolactinemia. Conclusion: In the present study, hyperprolactinemia was demonstrated as a positive and significant correlational factor for greater weight gain, manifested in higher levels of body mass index, a phenomenon explained by the increase in insulin resistance of this hormone, an increase in total cholesterol and triglycerides triggered, explained in the previous discussion. In turn, hyperprolactinemia appears to be a risk factor for developing high levels of thyroid hormones.