Distribución de genotipos de VHP, en muestras orofaríngeas de pacientes ecuatorianos, atendidos en SOLCA-Guayaquil 2018-2019.

Abstract

Introduction: Human Papilloma virus infection is considered as necessary causative factor for the development of various types of cancers, among them oropharyngeal carcinoma. Little is known about the prevalence of oral HPV infection in Ecuador. Determining the distribution of its genotypes will contribute to improve the available prevention strategies. Objective: This study aimed to determine the distribution of 32 HPV genotypes in 158 oropharyngeal samples, tested for HPV genotyping at National Institute for Oncology, Molecular Biology Laboratory (SOLCA Hospital Headquarters, Guayaquil-Ecuador), during the period 2018-2019. Materials and methods: This cross sectional study included data recovered from 158 oropharyngeal samples, included in routine molecular diagnostics and genotyped using reverse dot blot as technique. The general prevalence and gender prevalence were estimated. The genotypes distribution was presented as relative contribution (genotype contribution/positive cases). Results: The overall prevalence of HPV oral infection was estimated in 22.15% (35/158 cases), with genotypes, 6, 16, 11 and 18 as the most frequently detected.